Case Report: Rare invasive aspergillosis with brain abscess in a non-classically immunosuppressed patient, and pooled analysis of individual patient data (2000-2024).

ABSTRACT: Intracranial aspergillosis is uncommon but often lethal, especially in classically immunocompromised hosts. We report a 71-year-old man with poorly controlled diabetes (a non-classical risk factor) who developed bilateral frontal abscesses due to Aspergillus fumigatus. After an initial craniotomy with negative cultures and galactomannan, recurrent disease was confirmed by stereotactic biopsy with next-generation sequencing (NGS). Targeted azole therapy (voriconazole, isavuconazole) and multidisciplinary care led to marked clinical and radiographic improvement. We also pooled 343 published cases (2000-2024): overall mortality was 34.6%, and 21.8% among patients without classical immunosuppression (including some with non-classical factors such as diabetes). Improved survival in recen

SUBMITTER: Regmi M 

PROVIDER: S-EPMC12589800 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature