The Identification of Potential Treatment Targets to Reduce the Risk of Obesity-Related Complications: A Step Toward a Treat-to-Target Approach in Obesity Management.

ABSTRACT:

Aims

Obesity-related complications (ORCs) are associated with substantial health and economic burdens. Although treatment targets are routinely used for other chronic conditions, none currently exist in obesity management. We aimed to identify an adiposity measure that indicates a reduced risk of four ORCs.

Materials and methods

This population-based cohort study of patients aged 18-60 years used data from the UK Clinical Practice Research Datalink Aurum. Associations between absolute 10-year ORC risk and baseline body mass index (BMI), waist-height ratio (WHtR), and changes in adiposity measures after weight loss were calculated. Absolute values and changes in adiposity measures were evaluated as a proxy for achieving an absolute 10-year ORC risk similar to that of people w

SUBMITTER: Busetto L 

PROVIDER: S-EPMC12589817 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature