Abnormal myelin could be a mediator of childhood-trauma-induced depression: A quantitative synthetic MRI study.

ABSTRACT:

Objectives

Major depressive disorder (MDD) is a prevalent mental illness with unclear underlying pathophysiology that is often linked to childhood trauma. Emerging evidence suggests a potential association between myelin abnormalities and depression, highlighting the need for further understanding of these neurobiological connections in MDD patients. This study investigated the mediating role of abnormal myelin in the pathophysiology of MDD induced by childhood trauma via quantitative Synthetic Magnetic Resonance Imaging (SyMRI) technique.

Methods

MDD patients and healthy controls underwent SyMRI scanning to assess myelin content, T1, T2 and proton density (PD) values in the brain. Statistical analyses compared these values between groups and correlated them with clinical sy

SUBMITTER: Wen J 

PROVIDER: S-EPMC12589881 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature