Anabolic Effects of Salbutamol Are Lost Upon Immobilization.

ABSTRACT:

Background

Periods of muscle disuse occur during hospitalization, illness or the recovery from (sports) injury and lead to a rapid loss of muscle mass and the development of insulin resistance. Salbutamol is a fast-acting β2-adrenoreceptor agonist that may improve muscle protein synthesis and insulin sensitivity during experimental muscle disuse and thereby attenuate or preserve muscle mass; however, this has not yet been tested as a standalone intervention.

Methods

Effects of salbutamol treatment on muscle metabolism were studied in a randomized controlled trial using a human forearm immobilization model (n = 20). Before and after immobilization for 2 days, we measured whole-body glucose disposal, forearm glucose uptake and amino acid kinetics during fasting and hyperinsuli

SUBMITTER: de Jong JCBC 

PROVIDER: S-EPMC12589897 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature