Genomic Risk Prediction of Incident Atrial Fibrillation in Older Individuals Without Prior Cardiovascular Disease.

ABSTRACT:

Background

Polygenic risk scores (PRSs) may enhance atrial fibrillation (AF) risk prediction when added to conventional risk factors. Most AF-PRS studies, however, focus on individuals with existing cardiovascular disease, rather than initially healthy older adults followed prospectively.

Objectives

The objective of the study was to evaluate the predictive performance of a recent (2025) AF-PRS for incident AF in a cohort of healthy older individuals without prior cardiovascular events.

Methods

AF-PRS was calculated in 12,906 individuals aged ≥65 years without prior cardiovascular disease or AF at enrollment into the ASPREE (Aspirin in Reducing Events in the Elderly) trial. Cox proportional hazards models assessed HRs) per SD of AF-PRS, alone and with clinical risk fac

SUBMITTER: Fransquet PD 

PROVIDER: S-EPMC12589920 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature