Targeting MGLL: terazosin regulates glycerolipid metabolism to mitigate endothelial cell senescence.

ABSTRACT: Metabolic disorders often arise in senescent endothelial cells, which impair endothelial function, lead to diminished vasodilation, increase vascular stiffness, and ultimately contribute to CVD pathogenesis. Despite notable advancements, the molecular mechanisms driving endothelial senescence and its contribution to vascular aging remain incompletely understood, thereby limiting the development of effective therapeutic strategies. Here, we investigated the protective role of terazosin (TZ) against vascular endothelial senescence using both in vivo (aged mice) and in vitro (human umbilical vein endothelial cells) models, combined with senescence-associated β-galactosidase staining, lipidomics, and molecular docking simulations. TZ treatment significantly improved endothelium-dependent vasod

SUBMITTER: Huang J 

PROVIDER: S-EPMC12589924 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature