Elevated Homocysteine is Associated With Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease in a Sex- and Menopause-Specific Manner.

ABSTRACT:

Background and aims

Elevated hepatic homocysteine (Hcy) contributes to hepatic inflammation and fibrogenesis in metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to evaluate the association between serum Hcy levels and the risk of MASLD and hepatic fibrosis in a large, diverse population, accounting for clinical confounders and effect modifiers such as sex and reproductive status.

Methods

We analyzed 1999-2006 National Health and Nutrition Examination Survey data for 8253 adults (≥18 years) without hepatitis B/C, excessive alcohol use, or pregnancy. MASLD was defined using the fatty liver index (≥30), and fibrosis risk was assessed using age-adjusted Fibrosis-4 and nonalcoholic fatty liver disease fibrosis score among MASLD subjects (N = 5328). Assoc

SUBMITTER: Suzuki M 

PROVIDER: S-EPMC12589971 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature