Impact of Exercise on Clonal Hematopoiesis.

ABSTRACT:

Background

Clonal hematopoiesis (CH) is more prevalent in cancer patients and is associated with excess all-cause mortality (ACM) risk compared to patients without CH. Interventions to mitigate risk are not available.

Objectives

The objective of the study was to investigate whether exercise reduces CH prevalence and excess ACM risk of CH in cancer patients.

Methods

We integrated genomic sequencing data with detailed exercise and clinical annotation from 2 retrospective studies: 3,539 patients with solid tumors from the MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) and 1,142 patients with primary breast cancer from CANTO (CANcer TOxicities). Patients were classified as nonexercisers (ie, 0 metabolic equivalent of task-

SUBMITTER: Scott JM 

PROVIDER: S-EPMC12589976 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature