Amniotic membrane placement without endotamponade for optic nerve coloboma with extensive serous retinal detachment in papillorenal syndrome: A case report.

ABSTRACT:

Purpose

To report a rare case of serous macular detachment associated with optic nerve coloboma in a patient with genetically confirmed papillorenal syndrome, successfully treated with human amniotic membrane transplantation (hAMT) without endotamponade after the failure of initial surgery with inverted internal limiting membrane (ILM) flap.

Observations

A 21-year-old woman with a confirmed PAX2 gene variant presented with progressive visual decline in the left eye due to serous macular detachment associated with optic nerve coloboma. Initial management with pars plana vitrectomy (PPV), foveal-sparing ILM peeling, and inverted ILM flap placement over the optic nerve failed to achieve reattachment. A second surgery involving placement of a human amniotic membrane graft withou

SUBMITTER: Lucchini S 

PROVIDER: S-EPMC12590020 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature