Altered immune and inflammatory gene expression in prefrontal cortex of antipsychotic-free schizophrenia subjects.

ABSTRACT: Gene expression studies in dorsolateral prefrontal cortex (DLPFC) of subjects with schizophrenia have repeatedly reported alterations in immune and inflammatory responses as well as neuronal and mitochondrial processes. Whether the findings are due to schizophrenia and/or to the effect of antipsychotic (AP) drug exposure is particularly intriguing. In the present study, we performed a transcriptomic study in DLPFC of 16 schizophrenia subjects with no detectable AP blood levels at the time of death. Each schizophrenia subject was matched to a control subject for sex, age, postmortem interval and storage time of the samples. Weighted co-expression network analysis (WGCNA) of transcriptomic data identified 33 modules of co-expressed genes. One of these modules was significantly associated wit

SUBMITTER: Mas S 

PROVIDER: S-EPMC12590022 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature