Dual-action thioarylamide-based small molecules to target drug-resistant bacteria and chronic inflammation.

ABSTRACT: We report the synthesis and the antibacterial activity of a library of thioarylamide derivatives, which include N-19004, previously developed as Formyl Peptide Receptor 1 antagonist. These compounds were active against a broad spectrum of pathogens, including clinical strains of Staphylococcus aureus and Pseudomonas aeruginosa. N-19004 and its analog N-19004-S were proficient in biofilm growth inhibition and disruption. In a murine model of chronic Pseudomonas aeruginosa lung infection, N-19004 significantly reduced bacterial burden and inflammation at low doses. As revealed by Electron Paramagnetic Resonance and Scanning Electron Microscopy analyses, the antibacterial effect of N-19004 mainly derives from its interference with the bacterial membrane bilayer. The forma

SUBMITTER: De Fenza M 

PROVIDER: S-EPMC12590031 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature