Safety and functional evaluation of a synthetic lamina cover that replaces lost autologous spinal bone after laminectomy, in a sheep and human study.

ABSTRACT:

Background

Laminectomies involve removal of the lamina, usually to relieve pressure on the spinal cord. We are developing a synthetic lamina cover (SLC) that can replace the resected bone, functioning as an artificial shield, with the objective to minimize common postsurgical risks associated with laminectomies. The SLC is designed to be affixed to a common pedicle screw fixation system.

Methods

Lumbar laminectomies with posterior fusions were performed in 6 sheep and 30 human patients. Both cohorts were separated into 2 groups, where 1 group received the SLC to replace the lamina, whereas the other group did not. Otherwise, postsurgical care and medical attention were the same in both groups. After 26 weeks, the sheep were euthanized and histopathological and histomorphomet

SUBMITTER: Chen CK 

PROVIDER: S-EPMC12590038 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature