A "controlled assembly" strategy for constructing <i>Coptidis Rhizoma</i> self-assembled nanoparticles to ameliorate inflammatory damage in Atopic dermatitis.

ABSTRACT: Atopic dermatitis (AD) is a prevalent chronic inflammatory disorder requiring effective therapeutic intervention. Self-assembled nanoparticles derived from traditional Chinese medicine (TCM) decoctions have gained increasing attention for their potential clinical applications in AD treatment. However, the self-assembly process of TCM occurs simultaneously with the extraction of active ingredients, leading to poor stability and uniformity of the self-assembled nanoparticles, which results in unpredictable therapeutic efficacy. In this study, we propose an innovative "controlled assembly" strategy to improve the self-assembly process of decoction. Coptidis Rhizoma self-assembled nanoparticles (CR-SAN) were constructed via hydrochloric acid-assisted aqueous extraction followed by pH-dr

SUBMITTER: Song R 

PROVIDER: S-EPMC12590232 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature