Immunolyser 2.0: An advanced computational pipeline for comprehensive analysis of immunopeptidomic data.

ABSTRACT: Immunopeptidomics interrogates the peptide repertoire presented on the cell surface by major histocompatibility complex (MHC) molecules for T cell immune recognition. Advanced mass-spectrometry-based techniques have enabled rapid accumulation of immunopeptidomic data, posing a significant challenge for automated and efficient analysis of these large-scale datasets. To tackle this challenge, we introduced Immunolyser 1.0, a computational pipeline to streamline key analyses of immunopeptidomic data, including peptide length distribution, motif analysis, peptide clustering, and peptide-MHC binding prediction. Here, we present Immunolyser 2.0 with upgraded functionalities and an improved user interface. Major updates in Immunolyser 2.0 include (i) expanded functionality allowing analysis of mu

SUBMITTER: Munday PR 

PROVIDER: S-EPMC12590289 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature