Human coronavirus OC43 infection in human cerebral organoids: novel insights on pathogenesis and potential therapeutic interventions.

ABSTRACT:

Background

Since the COVID-19 pandemic, there has been a documented rise in the incidence of neurological manifestations among individuals complicated with encephalitis or myelitis. The spectrum of neurological symptoms associated with HCoVs infections is expanding. However, the infection characteristics and pathogenesis of seasonal HCoVs to the central nervous system remain obscure. No pharmacological agents have demonstrated the capacity to specifically and efficaciously mitigate the neurological symptoms induced by HCoVs infections to date.

Methods

We developed human cerebral organoids (HCOs) derived from human induced pluripotent stem cells and established a blood-brain barrier (BBB) HCOs co-culture model. We subjected these models to seasonal human coronavirus (HCoV) in

SUBMITTER: Liu J 

PROVIDER: S-EPMC12590701 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature