Sex differences in the prognostic value of urinary albumin-to-creatinine ratio for coronary artery disease and cardiovascular events in people with type 2 diabetes and normoalbuminuria.

ABSTRACT:

Background

Urinary albumin excretion is an established marker of cardiovascular (CV) risk in people with type 2 diabetes mellitus (T2DM). However, its prognostic significance within the normoalbuminuric range (< 30 mg/g) remains uncertain, particularly regarding sex-specific differences. This study examined whether urinary albumin-to-creatinine ratio (UACR; KDIGO A1 range) is associated with coronary artery disease (CAD) severity and 6-year major adverse cardiovascular events (MACE) in women and in men with T2DM and preserved kidney function (eGFR > 60 mL/min/1.73 m², UACR < 30 mg/g), treating sex differences as a co-primary objective.

Methods

We conducted a retrospective cohort study involving adults with T2DM who underwent diagnostic coronary angiography. Baseline associat

SUBMITTER: Siverio-Morales O 

PROVIDER: S-EPMC12590722 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature