Serum growth differentiation factor 15 trajectory predicts 28-day mortality in critically ill patients: a multicenter cohort study.

ABSTRACT:

Background

Growth differentiation factor 15 (GDF15) has been linked to critical illnesses, particularly cardiovascular and infectious diseases, but its dynamic patterns and prognostic value in critically ill patients remain unclear. This study investigates the predictive utility of serum GDF15 trajectories for 28-day mortality among patients in the intensive care unit (ICU).

Methods

In this multicenter, prospective cohort study, ICU patients were enrolled, and serum GDF15 trajectories during the first week were analyzed using group-based trajectory modeling (GBTM). The association between trajectory subtypes and 28-day mortality was assessed through hierarchically adjusted multivariable logistic regression. A cumulative index, "GDF15-load," was introduced to quantify overall

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12591050 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature