Palladium-catalyzed amidocarbonylation of thioethers: access to α-amide-substituted thioether derivatives.

ABSTRACT: Thioethers play a crucial role as structural components in a wide range of natural products, pharmaceuticals, and industrial materials, influencing their chemical characteristics and biological functions. Herein, we report a palladium-catalyzed aminocarbonylation reaction of thioethers with amines as nucleophiles. This palladium-catalyzed carbonylation reaction features a wide substrate scope and functional group tolerance, enabling the efficient C(sp³)-H aminocarbonylation of thioethers to afford the corresponding amides in good yields.

SUBMITTER: Mao X 

PROVIDER: S-EPMC12591059 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature