Nanocatalytic Neuroprotection and Neurological Recovery Post-Traumatic Brain Injury.

ABSTRACT: Traumatic brain injury (TBI) is a severe neurological disorder requiring novel therapeutic strategies. We developed ultrasmall catalytic Ce_0.7Zr_0.3O₂ nanozymes (CZs) and investigated their neuroprotective potential in combination with nimodipine, a calcium channel blocker. CZs effectively alleviated oxidative stress but were insufficient against calcium-mediated neuronal injury, while nimodipine alone inadequately mitigated oxidative damage. Combined therapy preserved blood-brain barrier integrity, reduced oxidative stress and neuroinflammation, and inhibited neuronal apoptosis, with CZs exerting potent effects even at low doses. Nimodipine synergistically regulated calcium overload, suppressed CaMKII activation, and enhanced functional recovery during late

SUBMITTER: Hong X 

PROVIDER: S-EPMC12591159 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature