Utility of Alpha-Fetoprotein and Protein Induced by Vitamin K Absence or Antagonist-II Kinetics in Predicting Radiologic Response and Survival in Unresectable Hepatocellular Carcinoma Undergoing Immunotherapy.

ABSTRACT:

Background

Alpha-fetoprotein (AFP) is currently the most commonly used biomarker for hepatocellular carcinoma (HCC) surveillance. However, protein induced by vitamin K absence or antagonist-II (PIVKA-II) may have a better prognostic role in some patients. The aim of this study was to investigate the prognostic roles of AFP and PIVKA-II kinetic changes in predicting outcomes in patients with unresectable HCC receiving immunotherapy.

Methods

Data were collected from subjects with Child-Pugh class A, and Barcelona Clinic Liver Cancer (BCLC) stage B or C HCC, who received immunotherapy from September 2021 to June 2023. The exclusion criteria included cases with normal values of AFP or PIVKA-II. The values of AFP and PIVKA-II at baseline and 4 weeks after initiation of therapy we

SUBMITTER: Lee SW 

PROVIDER: S-EPMC12591226 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature