Understanding the Role of All-Trans Retinoic Acid in Acute Myeloid Leukemia Cells.

ABSTRACT:

Background

All-trans retinoic acid (ATRA) has revolutionized the management of acute promyelocytic leukemia (APL) and has generated interest in differentiation therapy as means to reduce reliance on conventional chemotherapy in other subtypes of acute myeloid leukemia (AML). However, the precise relationship between immunophenotypic changes and morphological maturation during ATRA-induced differentiation remains poorly defined. This study aimed to investigate the phenotypic and morphological progression of HL60 cells treated with ATRA and to establish quantitative correlations between surface marker expression and cell morphology.

Methods

HL60 cells were treated with 1 µM ATRA. Expression of myeloid and monocytic surface markers (CD38, CD45, CD11b, human leukocyte antigen (H

SUBMITTER: Al Sadoun H 

PROVIDER: S-EPMC12591235 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature