Hemodialysis and its effects on glymphatic system function in end-stage kidney disease patients.

ABSTRACT:

Background

The glymphatic system, responsible for clearing metabolic waste from the brain, may be affected in patients with end-stage kidney disease (ESKD), potentially impacting brain health. This study investigates the effects of hemodialysis on glymphatic function in ESKD patients.

Methods

This prospective study enrolled ESKD patients along with age- and sex-matched healthy controls (HCs). Each ESKD patient underwent magnetic resonance imaging (MRI) scans before and after a single hemodialysis session to obtain diffusion tensor imaging (DTI) data. HCs underwent a single MRI scan. The analysis along the perivascular space (ALPS) index was calculated using DTI-ALPS to indirectly assess changes in glymphatic system function pre- and post-hemodialysis in ESKD patients and to

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC12591762 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature