First-phase ejection fraction as a potential early indicator for left ventricular function in cardiac amyloidosis.

ABSTRACT:

Background

Cardiac amyloidosis (CA) is crucial for prognosis in patients with light-chain amyloidosis, with left ventricular first-phase ejection fraction (LVEF1) being a more sensitive indicator for this condition than ejection fraction. This study aimed to assess LVEF1's value in informing the treatment and prognosis of patients with light-chain CA.

Methods

A total of 119 patients with light-chain amyloidosis and LVEF ≥50% and suspected CA according to echocardiography were enrolled. After validation via cardiac magnetic resonance (CMR) or abdominal fat biopsy, these patients were split into a CA group (n=72) and non-CA group (n=47). Based on first hospitalization, echocardiography and blood biochemical data were obtained. After 1 year of chemotherapy, echocardiography and

SUBMITTER: Huang T 

PROVIDER: S-EPMC12591782 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature