The value of multi-parametric magnetic resonance imaging (MRI) radiomics in predicting isocitrate dehydrogenase (IDH) wildtype with telomerase reverse tranase (TERT) promoter mutation in glioma.

ABSTRACT:

Background

Accurate preoperative prediction of gliomas is crucial for formulating personalized treatment decisions and assessing prognosis. With the release of the 2021 World Health Organization (WHO) classification of central nervous system tumors, molecular diagnostics have demonstrated even greater importance. Isocitrate dehydrogenase (IDH) is a significant marker for evaluating glioma prognosis, while the telomerase reverse tranase (TERT) promoter has a dual impact on glioma prognosis. In this study, we aimed to explore the application value of preoperative multi-parametric magnetic resonance imaging (MRI) radiomics in the prediction of IDH wildtype with TERT promoter mutation in glioma.

Methods

Preoperative MRI images and genetic data of 415 glioma patients from three c

SUBMITTER: Wang J 

PROVIDER: S-EPMC12591846 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature