A CART-based prognostic model for risk stratification of postoperative early recurrence in hepatocellular carcinoma with microvascular invasion.

ABSTRACT:

Background

Postoperative early recurrence (ER) poses a major threat to long-term survival in hepatocellular carcinoma (HCC), especially in patients with microvascular invasion (MVI). Although conventional staging systems provide prognostic guidance, they are often inadequate for capturing recurrence risk in this high-risk subgroup. To develop and validate a CART-based prognostic model tailored to ER risk stratification and assessment of long-term outcomes following curative hepatectomy in MVI-positive HCC.

Methods

A retrospective cohort of 440 patients with histologically confirmed HCC and MVI who underwent curative resection was analyzed. ER-associated predictors were identified via multivariable Cox regression and used to construct a classification and regression tree (CAR

SUBMITTER: Zeng J 

PROVIDER: S-EPMC12591875 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature