Magnetic resonance imaging fractal analysis of O(6)-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase wild-type glioblastoma.

ABSTRACT:

Background

The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter profoundly influences the response of glioblastoma (GBM) patients to temozolomide (TMZ) chemotherapy. This study evaluates the potential of magnetic resonance imaging (MRI) fractal analysis to predict the methylation status of the MGMT promoter in isocitrate dehydrogenase (IDH) wild-type GBM.

Methods

In this retrospective study, 303 GBM patients from two centers were included between 2018 and 2023. The training set consisted of 220 patients from the first center, and the independent validation cohort included 83 patients from the second center. Fractal dimension (FD) and lacunarity were extracted from T2-weighted and post-contrast T1-weighted (T1C) MRI sequences. Statistical ana

SUBMITTER: Xue C 

PROVIDER: S-EPMC12591892 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature