Association of body mass index changes with short-term mortality risks in ICU patients with sepsis across different admission BMI states: analysis of the MIMIC-IV database.

ABSTRACT:

Background

Static body mass index (BMI) is a known predictor of mortality in sepsis; however, the prognostic value of dynamic BMI trajectories across various admission BMI states remains unclear. This study aimed to quantify the dose-response relationship between ICU-acquired BMI changes and 30-day mortality and to determine BMI-specific thresholds for risk stratification.

Methods

This retrospective, multicenter cohort study analyzed 5,577 adult patients with sepsis from the MIMIC-IV database (2008-2022). To delineate the nature of the relationship between BMI change rate and 30-day mortality across distinct baseline BMI strata, we employed multivariable Cox proportional hazards regression coupled with restricted cubic splines. A two-segment linear regression model with a re

SUBMITTER: Liu W 

PROVIDER: S-EPMC12591966 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature