Establishment of prognostic signature based on neutrophil extracellular traps-related genes in acute myeloid leukemia: a bioinformatics analysis.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a hematological malignancy with a high incidence of febrile neutropenia during the first two treatment cycles. This study aims to develop a gene signature related to neutrophil extracellular traps (NETs) to enhance understanding of AML mechanisms and identify potential prognostic biomarkers.

Methods

A consistent cluster analysis was conducted on 151 AML patients from the TCGA dataset. A differential analysis was performed to identify the differentially expressed genes (DEGs) specific to different subtypes and the training cohort (normal vs tumour). The NETs-related differentially expressed genes (NR-DEGs) were obtained through the overlapping of the two sets of differentially expressed genes. Univariate Cox and Least absolute shrink

SUBMITTER: Shen Z 

PROVIDER: S-EPMC12592046 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature