Global trends in ambient particulate matter-attributable ischemic heart disease among the elderly (1990-2021).

ABSTRACT:

Background

Airborne particulate matter (PM), particularly PM₂.₅, poses a growing threat to cardiovascular health, especially among older adults. With intensified urbanization and industrial activities, PM₂.₅ has become a major factor contributing to ischemic heart disease (IHD), a leading cause of global mortality. These fine particles can penetrate pulmonary defenses, enter circulation, and trigger inflammatory and oxidative pathways that accelerate vascular damage. The elderly, whose physiological resilience declines with age, are particularly susceptible. While PM exposure's link to IHD is established, patterns by sex and age in older populations remain underexplored. This study assesses global, regional, and national shifts in PM-related IHD burden between 1990 and 2021, identi

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC12592073 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature