Interhemispheric EEG coherence as a candidate biomarker in gambling disorder: evidence of frontal hyperconnectivity and posterior disconnectivity.

ABSTRACT:

Background

Gambling Disorder (GD) is a behavioral addiction marked by impaired decision-making and poor impulse control. We investigated whether resting-state interhemispheric quantitative EEG (qEEG) coherence-a measure of functional connectivity between homologous cortical regions-could serve as a biomarker of GD.

Methods

Twenty-nine male patients with GD and 45 healthy male controls underwent resting-state qEEG recording. Coherence was computed for homologous electrode pairs across delta, theta, alpha, and beta bands. Group differences were analyzed using independent-samples t-tests; associations with disorder duration were assessed via age-controlled partial correlations.

Results

Consistent with our hypothesis, GD participants exhibited frontal pole hypercoh

SUBMITTER: Yılmazer E 

PROVIDER: S-EPMC12592092 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature