Distinct neuroprotective and anti-inflammatory effects of Kampo formulas ninjinyoeito and juzentaihoto in depression-like SAMP8 mice.

ABSTRACT:

Introduction

In contemporary aging societies, preventing and ameliorating mental and physical frailty is essential. Kampo formulas, including ninjinyoeito (NYT) and juzentaihoto (JTT), have been used traditionally to treat frailty in the elderly. NYT has been reported to alleviate psychological frailty such as depression and anxiety. This study aimed to clarify the mechanisms underlying the effects of these two Kampo formulas in the early stages of neurodegeneration associated with psychiatric disorders.

Methods

Genes affected by Kampo formulas were comprehensively investigated by administering JTT or NYT to senescence accelerated mouse prone 8 (SAMP8) mice, from 7 weeks, and by RNA sequencing of the hippocampus at 19 weeks when depression and anxiety behaviors typically eme

SUBMITTER: Maruko A 

PROVIDER: S-EPMC12592136 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature