FCGR2A defines prognostic immune subtypes and drives tumor progression in hepatocellular carcinoma.

ABSTRACT:

Background

The immunosuppressive nature of the HCC tumor microenvironment limits the effectiveness of current immunotherapeutic strategies. Identifying key immune-related regulators is essential for improving patient stratification and therapeutic outcomes.

Methods

Transcriptomic data from TCGA and GEO datasets were integrated to screen IRDEGs. Functional enrichment, co-expression, and PPI network analyses were performed to explore the biological context. Consensus clustering based on hub gene expression was used to define immune-related molecular subtypes. Immune infiltration characteristics, immune checkpoint expression, TIDE and IPS scores, and predicted immunotherapy responses were compared. FCGR2A expression was validated in clinical HCC tissues by immunohistochemistry

SUBMITTER: Zhong D 

PROVIDER: S-EPMC12592142 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature