Hydrogen sulphide alleviates depression-like behaviors by suppressing the hippocampal necroptosis-neuroinflammation-KP imbalance axis.

ABSTRACT:

Background

We have previously demonstrated that hydrogen sulfide (H₂S) is sufficient to attenuate depressive-like behavior induced by chronic unpredictable mild stress (CUMS), but its underlying mechanisms remain largely unknown. It is well known that necroptosis is a trigger of inflammation and neuroinflammation-induced kynurenine pathway (KP) imbalance is the main pathogenesis of depression. Meanwhile, H₂S plays a pivotal role in the inhibition of inflammatory pathways. Hence, the present study sought to investigate whether the antidepressant effect of H₂S is attributable to the inhibition of the axis of hippocampal necroptosis-neuroinflammation-KP imbalance.

Methods

The depression model of Sprague-Dawley (SD) rats was established by CUMS f

SUBMITTER: Yang SQ 

PROVIDER: S-EPMC12592148 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature