Transcription factor 25 modulates gametocytogenesis and ribosome biogenesis in the malaria parasite <i>Plasmodium falciparum</i>.

ABSTRACT:

Introduction

Plasmodium falciparum, the causative agent of severe malaria, predominantly reproduces through asexual stages within human red blood cells, with a small subset differentiating into transmissible gametocytes. TCF25 is recognized in other eukaryotes as a protein with dual roles: a transcriptional regulator and a key component of the Ribosome-associated Quality Control (RQC) complex. Nevertheless, the precise biological function of TCF25 in Plasmodium spp. remains inadequately elucidated.

Methods

To investigate the function of TCF25, we created a tcf25 knockout (tcf25_ko) parasite strain and conducted comparative transcriptomic analysis during the ring and schizont stages. Gametocyte induction experiments were performed to investigate th

SUBMITTER: Wu J 

PROVIDER: S-EPMC12592149 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature