The role of <i>NFKB1</i> and <i>NFKBIA</i> in immunoglobulin A vasculitis.

ABSTRACT:

Introduction

Immunoglobulin A vasculitis (IgAV) is an inflammatory disease mediated by B cells. Nuclear factor kappa B (NF-κB) is essential for B-cell development and maturation and plays a key role in autoimmunity and inflammation. In particular, the NF-κB canonical activation pathway genes NFKB1 (encoding NF-κB1) and NFKBIA (encoding NF-κB inhibitor alpha) have been identified as risk loci for several immune-mediated diseases, but their role in IgAV remains unclear. This study aimed to determine whether NFKB1 and NFKBIA represent novel genetic risk factors for IgAV pathogenesis.

Methods

The NFKB1 promoter variant -94 ins/del ATTG (rs28362491), six tag NFKB1 polymorphisms (rs77830930, rs1598856, rs7340881, rs4648055, rs464809

SUBMITTER: Batista-Liz JC 

PROVIDER: S-EPMC12592155 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature