Micro-geographic variation in antigenic diversity of PfEBA-175 region II in asymptomatic <i>Plasmodium falciparum</i> infections in Tanzania.

ABSTRACT:

Background

Malaria remains a major public health burden, and the development of effective blood-stage vaccines is complicated by extensive antigenic variation in Plasmodium falciparum antigens. PfEBA-175, a leading vaccine candidate, mediates erythrocyte invasion by binding to glycophorin A via its region II (RII), which is known to be highly polymorphic.

Methods

We examined the genetic diversity and antigenicity of PfEBA-175 region II (RII) in 172 asymptomatic P. falciparum isolates collected from Geita and Kigoma, Tanzania. Sequence diversity was assessed through nucleotide diversity (π) and analysis of selection pressure using d_N-d_S and Fu's Fs tests. A recombinant PfEBA-175 RII protein was expressed to evaluate antibody response in pla

SUBMITTER: Syahada JH 

PROVIDER: S-EPMC12592157 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature