Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity.

ABSTRACT:

Introduction

Naturally produced melatonin acts as an antioxidant and immunomodulator, regulating sleep and vital functions. Synthetic melatonin is widely used as a sleep aid by the general population, including U.S. military personnel. Immunomodulatory effects of melatonin on vaccines and therapeutics must be studied to develop and implement effective clinical practice guidelines, which will enhance the quality of life of the public and the military readiness. Here, we evaluated exogenous melatonin mediated immune modulation during seasonal influenza vaccination using the samples generated in the Melatonin and Vaccine Response, Immunity, and Chronobiology Study (MAVRICS) conducted by the Naval Medical Research Command (NMRC) and the Walter Reed National Military Medical Center (WRN

SUBMITTER: Oda K 

PROVIDER: S-EPMC12592183 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature