Benzophenone-3 remodels gut microbiota diet-dependently to exacerbate non-alcoholic fatty liver disease in zebrafish.

ABSTRACT: Benzophenone-3 (BP3), a prevalent organic UV filter found in aquatic environments and human tissues, poses potential metabolic risks. This study investigated the combined effects of BP3 (10 μg/L) and a high-fat diet (HFD, 24% crude fat) on non-alcoholic fatty liver disease (NAFLD) development in zebrafish, focusing on gut-liver axis disruption via microbiota. Co-exposure to BP3 and HFD significantly worsened hepatic steatosis, as evidenced by increased triglyceride levels, lipid droplets accumulation, and oxidative damage (elevated hepatic MDA levels and decreased hepatic CAT activity). Additionally, this combined exposure induced gut dysbiosis characterized by a marked decrease in Bacteroidota and Fusobacteriota, along with increased proportions of Proteobacteria and

SUBMITTER: Tao J 

PROVIDER: S-EPMC12592189 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature