P. falciparum EBA-181 ligand - searching for the receptor on human erythrocytes.

ABSTRACT: Malaria caused by Plasmodium is responsible for approximately 250 million clinical cases and 600,000 deaths per year, mostly in Africa. Our understanding of Plasmodium parasite biology remains incomplete. The key step of Plasmodium invasion is the blood stage, which is mediated by Erythrocyte binding-like (EBL) and Reticulocyte binding-like (RBL) proteins. Three P. falciparum EBL proteins and their receptors are functional: EBA-175 - Glycophorin A (GPA), EBL-1 - Glycophorin B (GPB), and EBA-140 - Glycophorin C (GPC). Because the fourth EBA-181 ligand recognizes the mysterious erythrocyte receptor Z, which remains unknown, we aimed to characterize its specificity and search for its receptor. The Surface Plasmon Resonance method was employed to evaluate the interaction of the recombinant EBA

SUBMITTER: Jodlowska M 

PROVIDER: S-EPMC12592255 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature