CAPRIN1 specifically mediates m⁶A modification of RIG-I RNA to inhibit Mycobacterium Tuberculosis infection.

ABSTRACT: Tuberculosis (TB), the leading cause of death from a single infectious agent, remains incompletely understood in its pathogenic mechanisms. Through population-based bioinformatic analyses, we identified m⁶A modifications may play a critical role in the infection dynamics of tuberculosis, with CAPRIN1 emerging as a TB-specific m⁶A regulatory factor. Molecular and cellular experiments demonstrated that CAPRIN1 regulates the m⁶A modification of RIG-I RNA through direct interaction with METTL3, further influencing downstream interferon-associated gene networks and modulating Mycobacterium tuberculosis (M. tuberculosis) infection. Moreover, we discovered that these molecular biological processes predominantly occur within cellular stress granules (SGs). In summa

SUBMITTER: Zhou L 

PROVIDER: S-EPMC12592324 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature