Relaxation of selective constraint on the sweet-taste receptor gene TAS1R2 in lorisiform primates.

ABSTRACT: Recent research has revealed considerable evolutionary diversity in umami-taste (amino acids and nucleotides) and sweet-taste receptor TAS1R genes across vertebrate species. To contribute to a growing understanding of how diet shapes taste evolution, we studied TAS1R genes in non-anthropoid primates with highly diverse diets, including members of the Strepsirrhini, comprised of Lorisiformes (lorises) and Lemuriformes (lemurs), as well as members of the Tarsiiformes (tarsiers). We employed a targeted capture (TC) approach specifically probing all the three mammalian TAS1R genes, i.e., TAS1R1 (for sensing umami), TAS1R2 (sweet) and TAS1R3 (required for forming a heterodimer), followed by short-read massive-parallel sequencing for three lorisiform, four lemuriform, and one tarsiiform species.

SUBMITTER: Ji Q 

PROVIDER: S-EPMC12592329 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature