Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells.

ABSTRACT: The molecular and functional changes in endothelial cells during disease progression such as cancer have been noted but the mechanism of their activation is still under-studied. Previously we discovered that tumor-derived Oncostatin M induced tumor-associated vascular phenotypes, and the activated endothelial cells in turn promoted tumor progression and metastasis of clear-cell renal cell carcinoma (ccRCC). However, the mechanism of Oncostatin M action remains unknown. Here, we reveal that Oncostatin M signaling triggers specific epigenetic reprogramming of endothelial cells through upregulation of lysine acetyltransferase 6B, leading to increased histone 3 lysine 14 acetylation (H3K14ac) in vitro and in vivo. H3K14ac-modified chromatins upregulate specific gene sets associated with hypoxi

SUBMITTER: Nguyen-Tran HH 

PROVIDER: S-EPMC12592350 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature