Investigating the impact of sex and reproductive aging on latent signatures of modifiable dementia risk factors.

ABSTRACT: Treating modifiable risk factors for dementia may serve to prevent maladaptive brain aging. These include, and are not limited to, obesity, hypertension, and other metabolic disorders. Nearly two-thirds of affected individuals are female, and emerging research has pointed to potential sex-specific factors, such as reproductive aging, as potent modifiers of dementia risk. Here, we leverage neuroimaging to characterize sex differences in the neural signatures of modifiable dementia risk factors, examining their relationship with brain anatomy, and integrate female-specific factors related to menopause history in a sex-specific analysis. Using cross-sectional data from the UK Biobank, we selected a cohort of 31,711 (age 44-82, 55.2% female/44.8% male) participants without diagnosed neurologic

SUBMITTER: Mukora A 

PROVIDER: S-EPMC12592373 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature