Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention.

ABSTRACT: Mind-body interventions offer promising avenues for improving physical and mental health, yet the comprehensive biological effects of increasingly popular mind-body retreat interventions remain poorly understood. The neural and molecular effects of a 7-day retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals are investigated in an observational study on 20 healthy human participants randomly selected from 561 retreat participants. BOLD fMRI functional connectivity during rest and meditation and whole plasma proteomics, metabolomics, exosome-specific miRNA transcriptomics, and neurite growth and real-time metabolism cellular assays are compared pre- and post-intervention. Meditation decreases functional integration in the default mode (p = 0

SUBMITTER: Jinich-Diamant A 

PROVIDER: S-EPMC12592435 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature