Isolation and characterization of bacteriophages for carbapenem resistant Enterobacter cloacae complex strains.

ABSTRACT: There has been an increased interest in phage therapy for the treatment of antimicrobial resistant bacterial infections due to the decreasing effectiveness of antibiotics. While phage therapy has been successful, it often requires time to isolate and characterize phages suitable for phage therapy. Here, we isolated and characterized three phages against carbapenem-resistant Enterobacter cloacae complex (ECC) strains to potentially be applied in phage therapy. ECC strains commonly cause sepsis and urinary tract infections in hospitals and are designated as a pathogen of critical importance for its global prevalence and high instance of antimicrobial resistance. Initially, a total of 96 phages were isolated using a collection of diverse clinical ECC strains. Three phages were selected for ge

SUBMITTER: Imanaka M 

PROVIDER: S-EPMC12592470 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature