A comprehensive molecular atlas of the mesenchymal cell types in the mouse liver.

ABSTRACT: The liver plays crucial roles in many essential physiological processes, and its impaired function due to liver fibrosis from various causes is an increasingly significant health issue. The liver's functionality relies on the precise arrangement of its cellular structures, yet the molecular architecture of these units remains only partially understood. We created a comprehensive molecular atlas detailing the major cell types present in the adult mouse liver through deep single-cell RNA sequencing. Our analysis offers new insights into hepatic endothelial and mesenchymal cells, specifically highlighting the diversity of cells in the periportal microvasculature, the sinusoids, and the portal vein, the latter exhibiting a mixed arterio-venous phenotype. We identified distinct subpopulations o

SUBMITTER: Pietila R 

PROVIDER: S-EPMC12592516 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature