Neutrophil extracellular traps predict poor response and prognosis in non-small cell lung cancer immunotherapy.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have improved outcomes in non-small cell lung cancer (NSCLC), yet reliable biomarkers for predicting response remain limited. Neutrophil extracellular traps (NETs) may influence tumor immunity, but their clinical significance in NSCLC is unclear.

Objectives

To evaluate the predictive and prognostic value of NETs in advanced NSCLC patients treated with chemo-immunotherapy.

Design

A retrospective cohort study.

Methods

Pretreatment formalin-fixed paraffin-embedded biopsies from 46 stage IV NSCLC patients receiving first-line chemo-immunotherapy were analyzed by multiplex immunofluorescence to quantify NETs, CD8⁺ T cells, and cancer-associated fibroblasts (CAFs). Survival and correlation analyses were perfor

SUBMITTER: Lv J 

PROVIDER: S-EPMC12592660 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature