Sleep Apnea Specific Hypoxic Burden in Children With Down Syndrome and Typically Developing Children.

ABSTRACT: Hypoxic burden (HB) is a measure incorporating frequency, depth and duration of respiratory event-related desaturations. While HB is associated with cardiovascular disease in adults with obstructive sleep apnea (OSA), it has not been assessed in typically developing (TD) children with OSA, nor in children with Down syndrome (DS), who have a higher incidence of OSA with more severe hypoxia. We assessed whether HB in these children was related to heart rate variability (HRV), an indicator of cardiovascular outcomes. Children (3-19 years, n = 44) with DS and TD children matched for OSA severity, age and sex underwent overnight polysomnography and were grouped into primary snoring (PS), Mild or Moderate/Severe (MS) OSA. HRV was analysed using power spectral analysis of the electrocardiograph.

SUBMITTER: Walter LM 

PROVIDER: S-EPMC12592817 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature