Associations between psychedelic use and adverse outcomes in substance use disorders: a real-world EHR-based cohort study.

ABSTRACT:

Aims

To examine associations between psychedelic use and adverse health outcomes, including overdose, relapse, mental health crises, and hospitalizations, among individuals with substance use disorders (SUD), and to compare these outcomes across different treatment modalities including anesthetics and outpatient SUD services.

Design

Retrospective cohort study using propensity score-weighted quasi-Poisson regression models to estimate adjusted incidence rate ratios (aIRRs).

Setting

Data were drawn from Oracle EHR Real-World Data™ comprising 138 U.S. health systems restricted to those ≥12 years old from January 1, 2000, to August 31, 2023.

Participants

3,209,798 patients with a documented SUD diagnosis from 2000 to 2023. Patients with a prior history of psychedel

SUBMITTER: Qeadan F 

PROVIDER: S-EPMC12592884 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature