Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions.

ABSTRACT: A neuropathology examination after death remains the gold standard for differentiating between Alzheimer disease (AD) and AD and related dementias (ADRD). Increasing interest and familiarity with digital imaging highlights recent shifts to modernize pathology workflows by leveraging technology that automates imaging and analysis. This review provides an overview of digital pathology technologies and their associated infrastructure, available open-source and proprietary digital pathology software, relevant background on neurodegenerative histopathological features, and computational research. It further examines recent developments in digital pathology in neurodegenerative disease research with an emphasis on machine learning. We discuss evidence supporting how recently developed technologi

SUBMITTER: Rosado AM 

PROVIDER: S-EPMC12592941 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature